Histone Acetylome-wide Association Study of Autism Spectrum Disorder.Li H, Courtois ET, Sengupta D, Tan Y, Chen KH, Goh JJL, Kong SL, Chua C, Hon LK, Tan WS, Wong M, Choi PJ, Wee LJK, Hillmer AM, Tan IB, Robson P, Prabhakar S. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors.Postdoctoral fellows: Machine Learning and Mathematical Analysis of Spatial Transcriptomics Dataīioinformatics Specialists: Machine Learning and Genome Data Analytic HCA Barcelona 2019, HCA Equity Addis Ababa 2019ģrd Annual HCA Asia Meeting, Singapore: Single Cell Algorithms Human Cell Atlas, Asian Immune Diversity Atlas (AIDA): Labroots webinar: Single cell algorithms, application to colorectal cancer Straits Times interview: Histone acetylation changes in autismĬhannel News Asia interview: Histone acetylation changes in autism Earlier work explored the contribution of gene regulatory elements to human origins ( Prabhakar, Noonan et al., Science 2006 Prabhakar et al., Science 2008).Ĭentre for Big Data and Integrative Genomics (c-BIG) We have also uncovered fundamental properties of transcription factor binding to genomic DNA ( Jankowski et al., Genome Res 2013) and demonstrated that H2BK20ac is a distinctive signature of enhancers and cell-type-specific promoters ( Kumar, Rayan, Muratani et al., Genome Res 2016). Major achievements include the first single-cell transcriptomic analysis of colorectal tumors ( Li, Courtois et al., Nat Genet 2017), the first study of histone acetylation changes in autism spectrum disorder ( Sun, Poschmann et al., Cell 2016), the first large-scale study of variants that alter histone acetylation and contribute to disease susceptibility ( del Rosario, Poschmann et al., Nat Methods 2015) and the first unified signal-processing method for peak detection in whole-genome profiling data ( Kumar et al., Nat Biotechnol 2013). The methods we develop have spawned research collaborations with multiple industry partners spanning biotech, IT and pharma. For example, we are engaged in team science to discover markers of immunotherapy response and develop new imaging-based diagnostic technologies. In addition to curiosity-driven science, we pursue inventions and discoveries that will (hopefully) make a difference in the world. This involves statistics, machine learning and extensive benchmarking for performance and scalability. We also develop cutting-edge algorithms and pipelines for deriving biological insights from large datasets. In particular, we use single-cell RNA-seq, cohort-scale histone ChIP-seq and other NGS technologies to understand autism, psychiatric drug response, lung and colon cancer, chronic myeloid leukemia, autoimmune disorders and host response to infection. The Prabhakar Lab uses a combination of high-throughput omics assays (wet-lab) and data analytics (dry-lab) to study gene-regulatory mechanisms of human diseases. Thus, gene regulation lies at the heart of disease mechanisms and treatment response. In addition, transcriptional and epigenetic dysregulation are known to drive tumorigenesis, tumor progression and drug resistance. The majority of genetic mutations responsible for common diseases reside within gene-regulatory sequences such as enhancers, promoters and insulators. Single-Cell In Situ Spatial Omics at Subceullar Resolutionĭisease Mechanisms, Therapeutics, Diagnostics, Omics, Algorithms, Data Analysis.Spatial and Single Cell Genomics Platform.Epigenetic And Epitranscriptomic Regulation.Precision Medicine And Population Genomics.Post Doctoral Fellows and Research Associate.Junior Principal Investigator / GIS Fellows.Through the creation of data models, organizations can achieve a clear and structured understanding of their data, facilitating its storage, retrieval, and utilization in various business processes and analytical activities. It plays a vital role in ensuring data quality, integrity, and consistency, making it a cornerstone of effective data management and decision-making. It involves creating a visual or mathematical representation of data, often in the form of diagrams or schemas, to define how data elements are related and how they are stored within a database or system.ĭata modeling serves as a critical foundation for designing, building, and managing databases, as well as for developing software applications that rely on data. Data modeling is a systematic process of structuring and organizing data to make it accessible, understandable, and efficient for use in information systems and databases.
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You pick the features you want from the plugin list (see the table below for our free and paid plugins), and add them to the editor.Īll you then do is assemble the components (either through APIs or coding), customize parts (if you desire) and draw on our decades-long experience in building and maintaining rich text editors. The rich text editor adapts to your needs with customization available from the different TinyMCE plugins. TinyMCE has been engineered so that it’s adaptable to you and your needs. Anyone can access the project and have access to a rich text editor when they need it.It’s supported by a community, and developed in a collaborative way.It’s transparent, with development happening in the open.Open source availability has several advantages for users, which is why TinyMCE continues to be open source: TinyMCE became available as open source software, in 2004 with the TinyMCE 1.0 release (by MoxieCode). Then in the early 1990s, the first operating system that could be classified as open source was released. Open source first appeared in the 1970’s and 1980’s. There's more detail on the differences between these licenses, in the following sections. Whereas in TinyMCE version 6, the core TinyMCE editor runs under an MIT License. This is a distinct from a GPL licence, which is a copyleft licence. When it comes to licensing, the TinyMCE version 5 series makes use of an LGPL license. The TinyMCE core editor is free to use for commercial and noncommercial purposes. Why is TinyMCE free? What parts of TinyMCE are free? How do you get started with our free WYSIWYG core editor? TinyMCE core free plugins TinyMCE premium paid features TinyMCE license and terms of use Is TinyMCE free? This article explores the why, how and what parts of TinyMCE are free – the core editor, Premium Plugins, and TinyMCE licensing. 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If you add Feel free to add the description of your page. This part is probably temporary, to help reorganize documents about scenery enhancement. 1.2.2 Technical concepts and experimental generation toolsĭescription of the content of the articles by categories.1 Description of the content of the articles by categories.Static objects are typically prominent buildings while shared objects are typically objects used often, for example power pylons.Īll of this can and should be improved over time, and experimentation is both possible and encouraged (but work in small steps, so you can learn from small mistakes). In addition the scenery is populated with objects, either static objects that only occur once, or shared objects that are included with FlightGear and/or the scenery and are used in many places. The airports are also part of the terrain mesh, in which the various runway, taxiway and apron materials are encoded as scenery mesh triangles as well. Using that information the terrain is textured based on a material configuration, sometimes procedurally (in essence partially through configuration of algorithms and not by artwork alone). The triangular terrain mesh has some information like land class encoded in each triangle. The scenery is split into 1 x 1 degree scenery tiles. The scenery in FlightGear consists of a terrain mesh, terrain materials (which includes textures) and scenery objects. There is many ways to enhance scenery in FlightGear. Insert your objects into your favourite city using this guide.Note As of December 2015 this page is still rather a listing of the topics of most of the articles in the category rather than an introductory summary of different ways to enhance the scenery.Import PDB files, increase the size, rotate and manipulate as needed.Get the ePMY version of Blender or another 3D design software.Here we'll talk a bit about how we actually did it. Need more of a challenge? Make the betasheet smaller. To make it easier, we've put a nice flat landing pad there for you. Land a helicopter on the chromophore of RFP. Bonus: The larger the aircraft you can fly through, the better. (Right in time for the world finals :) ). In your glider, fly down through the helical constant domain of the flagellin monomer, landing safely in the Boston airport. Run flightgear and pick to take off from the Boston Airport! (ID:KBOS)īelow are a series of challenges that we have made in our level: Challenge #1: Flight of the Flagellin.Copy the Objects and Terrain folder to your Flightgear Scenery folder, ex: c:\Program Files\FlightGear\data\Scenery.Replace YOURPATHHERE with the file path to your downloads folder, or wherever you choose to store the protein models. Download and extract the map files: proteinflight.zip.Next, download and install the Flight of the Flagellin Maps! We wish we could make this a little bit easier but, we're inexperienced! Follow these step by step instructions: This kind of computer modelling is common practice in drug design.įirst download and install the game from Then, using this same idea, we can power docking experiments, in which players have to try and land a ligand in the active site of an enzyme, for example. More specifically, we can swap out that plane model for, say, a ligand. The higher your score, the better you did, and your solution can actually contribute to scientific data. Something like this could also lead into new games, like EteRNA or Fold-it, in which the player is assigned the puzzle of solving a protein or RNA structure. With the amount of work that went into getting this data, it's hard to say whether we're taking full advantage of it and using it to its full potential, or just completely bastardizing it. Now in this case, you're flying our somebody's hard earned scientific data instead. Lots of people play flight simulators just to fly around some generated landscape. It's also really surreal to be bringing some of the smallest units of life, and exploring them, in the setting of some of the largest man-made vehicles.įlying is just fun. It seems pretty ridiculous, but this could be a great way of teaching protein or molecular structure to people both young and old. What is this page really? Well, we recently discovered how easy it is to import 3D protein structures into an open-source flight simulator called FlightGear. Flight of the Flagellin Flight of the Flagellin takes protein structures and give them a hilarious, fun, new perspective. If you are passing left you typically want to pass the 2 of Clubs. If you have both the 2 of Clubs and Ace of Clubs you should pass one of them.The Ace of Clubs is less risky than other Aces since you can lay it on the first trick and players are prohibited from laying any Hearts or the Queen of Spades in the opening hand.When swapping cards it is usually best to pass along Queen, King, or Ace of a suit unless you are trying to Shoot the Moon.If you have the Ace, King, or Queen of Spades & few low spades you should pass the high Spade cards unless you want to shoot the moon.Having a large number of low value Spades (anything below the Queen) lowers the odds you will get stuck eating the Queen of Spades. Try not to lay off low ranking Spades as someone may send you the Queen, King or Ace.In general a great strategy to have is to try to have 3 or fewer suits if possible so that you have flexibility in laying off cards.When you pass across the person both knowns what you sent them and what they sent you.Likewise the person who passes you cards knows that they sent you.When you pass left or right the person who receives them knows what you gave them & may be able to infer your strategy based on that.The passing cards phase is almost as important as the order in which you lay cards.they have nothing but Hearts remaining in their hand.a Heart has already been laid & the suit is broken.Players may not lead with a Heart unless either:.Players may not lay the Queen of Spades or any Hearts on the opening hand.Whoever has the 2 of clubs starts the game by laying it.Players must follow the suit led when laying a card if they hold that suit in their hand.Before play begins players may be required to exchange 3 cards with other players.When someone hits 100 points the game is over and whoever has the lowest total score thusfar wins. Players continue to play new hands until someone hits 100 points.If a player manages to capture all 13 hearts and the Queen of Spades then they score zero points and all other players have 26 points added to their score.The winner is whoever has the least points at the end of a hand. The Queen of Spades is worth 13 points.Each Heart inside won tricks is worth a point.If you win a trick and there is a Heart in it then you score a point.Whoever wins a hand leads the next hand.If there are no Hearts and no Queen of Spades in the hand then no points are scored.Whoever lays the highest card in the suit which led wins the hand.The menu has buttons to resume the game, start a new game or read game rules. The game has buttons for sound control and bringing up the menu in the upper right corner.Use your mouse left click on the cards you want to pass at the beginning of a hand.The welcome screen has a sound control button in the upper right corner.Click on the yellow PLAY button on the game’s welcome screen to start your game.Try to score the fewest points by not winning tricks which contain a heart or the queen of spades in them. In addition to its cleaning capabilities, CCleaner also features an App Manager that allows you to uninstall multiple apps with ease. CCleaner’s cleaning feature wipes cache data, purges empty folders, and deletes various histories, effectively freeing up storage space. While the desktop version of CCleaner has faced some controversies, the Android app offers a reliable solution for cleaning and optimizing your device. CCleanerĬCleaner, a well-known desktop app for reclaiming disk space, also has an Android version. It’s an easy and free app that effectively gets the job done without any bloat.ĭownload: Files by Google (Free) 2. Unlike some apps that bundle in RAM optimizers and other features you don’t really need, Files by Google focuses solely on cleaning and organizing your device’s storage. What sets Files by Google apart from other cleaner apps is its simplicity and lack of unnecessary extras. Going the extra mile, Files by Google offers an ad-free experience and includes a fast offline file transfer service. This application not only suggests files for deletion, including old memes and unused apps but also serves as an efficient file manager. This automated cleaning process efficiently identifies and removes the biggest space hogs on your device. Upon opening the app, you’ll find a Clean tab that provides options to clear out junk files, duplicates, old screenshots, and unused apps. Developed by Google itself, this app offers easy-to-use tools to identify and remove unnecessary files from your device. One of the best Android cleaner apps worth considering is Files by Google. However, having any of the cleaner apps listed below lends a helping hand in identifying junk files and getting rid of duplicate media. Android devices are designed to manage their storage and memory efficiently, making regular maintenance unnecessary for most users. While they may seem like an easy solution to free up storage space and boost performance, it’s worth noting that most Android devices are already equipped with built-in features that handle multitasking effectively. These apps can help you keep your Android tablet clean and running smoothly without falling for tricks that might not actually help.īefore getting into nitty gritties of the best Android cleaner apps, it’s important to understand the raw truth about these apps. To make things easier for you, we picked out the three best cleaner apps from the Play Store. But, be careful about fancy features that cleaner apps promise to make everything super optimized-they might not always do what they say. Well, the answer is, yes, you can! These apps can help tidy up your tablet by removing files you don’t need and clearing out the junk that takes up space. Google made Android powerful enough at multitasking, so you might not need these cleaner apps as much.īut, if you have an Android tablet, you might be wondering if it’s a good idea to use a cleaner app. But now, it all seems like a narrative that barely holds any ground. For a long time, people thought Android Cleaner apps were essential for making Android devices work better. If your TIL is found on this list, it will be removed. This list was compiled from /r/todayilearned community suggestions by its members.More information available on the TIL FAQ and wiki. Please report spam, inaccurate or otherwise inappropriate posts by messaging the moderators, as this helps us remove them more promptly! If your post does not appear in the new queue and you think it meets the above rules, please contact the moderators (include a link to your post, not your story). Please see the wiki for more detailed explanations of the rules, as well as additional rules that may not be listed here "TIL you can click on widgets in WidgetMaker 1.22").Īll NSFW links must be tagged (including comments). No submissions related to the usage, existence or features of specific software/websites (e.g. "TIL the definition of a word." Word definitions/translations/origins are not appropriate here.instead, or be more specific (and avoid the word "about"). " and other broad posts don't belong on TIL. Starting your title with a why/what/who/where/how modifier should be unnecessary. Titles must be able to stand on their own without requiring readers to click on a link.not "TIL something interesting about bacon"). Make them descriptive, concise and specific (e.g.Rephrase your post title if the following are not met: Posts that omit essential information, or present unrelated facts in a way that suggest a connection will be removed. Social and economic issues (including race/religion/gender).Recent political issues and politicians.This includes (but is not limited to) submissions related to: No politics, soapboxing, or agenda based submissions. Any sources (blog, article, press release, video, etc.) with a publication date more recent than two months are not allowed. No personal opinions, anecdotes or subjective statements (e.g "TIL xyz is a great movie"). Videos are fine so long as they come from reputable sources (e.g. Images alone do not count as valid references. Please link directly to a reliable source that supports every claim in your post title. Submit interesting and specific facts that you just found out (not broad information you looked up, TodayILearned is not /r/wikipedia). You learn something new every day what did you learn today? Īmong the free content released with the game was the Corvette G6.R, Nissan GTR, Chevrolet Camaro GT3 (released in August 2013) and among the race tracks Silverstone and Lime Rock Park. In November 2014, a new build was released with a new tire contact patch physics, although it wasn't yet applied to any car. Tire degradation was added with a beta build 146 on February 4, 2013, along with other related tyre physics updates. Development by ISI after release (2013-2016) After the December 20, 2012, release (Update 10, Build 134) Test Build 49 has been out of beta since early 2013, and the official Steam store page retrospectively listed it as released on Ma(which corresponds to build 198). On January 10, 2012, the first open beta (Test Build 49) was released. In December 2011, more features were confirmed to be included in the upcoming open beta, including rain, wet/dry track transitions, dynamic track elements (groove/marbles), new tire model, new physics, and a new collision model. In October 2010, Camaj revealed in an extensive interview plans for including licensed content, a new reworked UI, inclusion of dynamic weather, new innovative dynamic racing surface technology, improvements to the AI logic, and a new force feedback system with lower input lag and much faster and more direct steering rack forces, similar to the popular third party developed RealFeel plug-in for rFactor. Later that month, he revealed more details about the upcoming simulator alongside additional in-game screenshots. The public first became aware that the development of rFactor 2 was underway when Gjon Camaj of Image Space Incorporated posted WIP in-game screenshots on Twitter in early March 2009. Development From announcement to open beta (2009-2012) At the same time, rFpro continues to use the developments made by ISI to the rFactor codebase. rFactor 2 also incorporated code that was developed for rFpro. From this point on, the software engine would be referred to as isiMotor2.5. Image Space Incorporated took the experience from isiMotor2 and rFactor Pro and began the development of rFactor 2. isiMotor2 also laid the foundation for rFactor Pro, a software simulation engine used by real-life racing teams and car manufacturers, including most of the current Formula One grid and NASCAR manufacturers. IsiMotor2 was further licensed to companies such as Slightly Mad Studios, Reiza Studios, and 2Pez Games. This title became rFactor, released in 2005, which was the first ISI title using the software engine referred to as isiMotor2. Image Space Incorporated then made a racing simulator with open architecture and provided tools for the modding community to create third-party content. After the release of F1 Challenge '99-'02, isiMotor was licensed to another company for the first time, SimBin, who went on to produce popular retail sim racing titles GTR and GTR 2. iMotor is an umbrella term that covers every component of the software engine, including the graphics engine gMotor and the physics engine Motor. Background Īfter the initial success of Sports Car GT (1999), Image Space Incorporated used its self-developed software engine Motor1 for several racing titles, including the Formula One simulators F1 2002 and F1 Challenge '99-'02. It features advanced physics, suspension, and tire model. RFactor 2 is designed to simulate any type of multi-wheeled vehicle of any era, including four-wheeled and six-wheeled vehicles with either two or four steered wheels. Much of its source code is derived from rFactor Pro, which is also used by professional racers and most of the Formula One teams and NASCAR manufacturers. Like its predecessor rFactor, rFactor2 is designed to be modified and used by professional racing teams for driver training and race car development. RFactor 2 is a computer racing simulator developed by Image Space Incorporated (renamed Studio 397 in 2016, acquired by Motorsport Games in 2021) and released for Windows in 2012. Read more about the Cambridge English range of qualifications and tests, and find out how they can help you improve your English language skills. Get breaking news, powerful stories and smart analysis, all ad-free. Unrivaled sports coverage across every team you care about and every league you follow. Red Giant Automatic Duck Media Copy 4.0.3 + serials. Red Giant Automatic Duck Media Copy 4.0.4 WIN-MAC + keys, Red Giant Automatic Duck Ximport AE 1.0.4 MAC + keys (FULL) Red Giant Complete Suite 2016 () + Serial Keys. Red Giant Color Suite 11.1.4 + keys + User Guides and Extras (FULL) WIN-MAC. 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